2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123669
    R-138727
    		Inhibitor
    R-138727, the thiol-containing active metabolite of Prasugrel, is an irreversible platelet P2Y12 receptor inhibitor. R-138727 inhibits ADP-induced platelet aggregation.
    R-138727
  • HY-125989B
    2-Methylthio-AMP diTEA
    		Antagonist ≥98.0%
    2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation.
    2-Methylthio-AMP diTEA
  • HY-N7032S1
    Uridine 5′-diphosphoglucose-13C6 disodium
    		98.35%
    Uridine 5′-diphosphoglucose-13C6 (UDP-D-Glucose-13C6) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032). Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.
    Uridine 5′-diphosphoglucose-<sup>13</sup>C<sub>6</sub> disodium
  • HY-N7740
    Adenosine 2',5'-diphosphate sodium
    		Antagonist 99.0%
    Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist. Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors.
    Adenosine 2',5'-diphosphate sodium
  • HY-113044
    Uridine 5′-diphosphoglucose
    		Agonist
    Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.
    Uridine 5′-diphosphoglucose
  • HY-111755
    P2Y12 antagonist 2
    		Antagonist
    P2Y12 antagonist 2 is a potent P2Y12 receptor antagonist. P2Y12 antagonist 2 exhibits excellent antiplatelet aggregation potency with an IC50 value of 2.94 μM as well as antithrombotic efficacy in a rat ferric chloride model. P2Y12 antagonist 2 shows a superior safety profile than Clopidogrel (HY-15283) in a rat tail-bleeding model. P2Y12 antagonist 2 can be used to research thromboembolic disorders.
    P2Y12 antagonist 2
  • HY-19638
    Cangrelor
    		Antagonist
    Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist.
    Cangrelor
  • HY-108661
    NF546
    		Agonist
    NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells.
    NF546
  • HY-100254
    TAK-024
    		Inhibitor
    TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.
    TAK-024
  • HY-RS09931
    P2RY4 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY4 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY4 Human Pre-designed siRNA Set A
  • HY-D1199
    Blue FPG-A trisodium
    		Antagonist
    Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2).
    Blue FPG-A trisodium
  • HY-108651
    Uridine-5'-O-(3-thiotriphosphate) trisodium
    		Agonist
    Uridine-5'-O-(3-thiotriphosphate) trisodium, a stable analogue of UTP, is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability.
    Uridine-5'-O-(3-thiotriphosphate) trisodium
  • HY-17459R
    Clopidogrel hydrogen sulfate (Standard)
    		Inhibitor
    Clopidogrel (hydrogen sulfate) (Standard) is the analytical standard of Clopidogrel (hydrogen sulfate). This product is intended for research and analytical applications. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.
    Clopidogrel hydrogen sulfate (Standard)
  • HY-146499
    Antiplatelet agent 2
    		Inhibitor
    Antiplatelet agent 2 (compound 7p) is a Ticagrelor analoguehas, possessing antiplatelet activity. Antiplatelet agent 2 can be used for researching platelet aggregation.
    Antiplatelet agent 2
  • HY-110265
    SAR216471 hydrochloride
    		Antagonist
    SAR216471 hydrochloride is a P2Y12 receptor antagonist. SAR216471 hydrochloride has antiplatelet and antithrombotic activities in vivo.
    SAR216471 hydrochloride
  • HY-134361
    ATP-γ-S tetrasodium
    		Agonist
    ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.
    ATP-γ-S tetrasodium
  • HY-174153
    PSB-22219
    		Ligand
    PSB-22219 is a highly selective non-nucleotidic ligand acting on P2Y12 receptors (KD=4.57 nM). PSB-22219 is promising for research of P2Y12 receptor-associated neuroinflammation.
    PSB-22219
  • HY-177726
    UTPU trisodium
    		Agonist
    UTPU (trisodium) (Compound 19) is a selective P2Y6R agonist with an EC50 of 0.4 μM. UTPU (trisodium) can activate the intracellular calcium signaling pathway mediated by P2Y6. UTPU (trisodium) can be used for the research of inflammation.
    UTPU trisodium
  • HY-115273
    MRS-2179
    		Antagonist
    MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with KB of 0.177 μM.
    MRS-2179
  • HY-RS09929
    P2ry2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry2 Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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